High-protein spinach artichoke chicken casserole – just saying those words makes my mouth water! You know that feeling when you’re craving something creamy, comforting, and satisfying, but you also want to fuel your body with good nutrition? That’s exactly how this recipe was born.
I’m Emeli, and as someone who’s spent years in professional kitchens and countless evenings cooking for family and friends, I’ve learned that the best dishes are the ones that make you feel both satisfied and nourished. This casserole delivers on both fronts – it’s the kind of meal that hugs you from the inside while packing a serious protein punch.
After years of experimenting with healthier versions of classic comfort foods, I’ve discovered the secret to creating dishes that don’t compromise on flavor. This recipe combines the beloved flavors of spinach artichoke dip with tender, perfectly seasoned chicken and a protein-rich cottage cheese base that will change how you think about healthy eating.
In this post, I’ll walk you through everything you need to know: why this recipe works so beautifully, how to choose and prep your ingredients for maximum flavor, step-by-step cooking instructions that ensure perfect results every time, and my favorite variations to keep things exciting.
Why This High-Protein Spinach Artichoke Chicken Casserole Recipe Works
There’s something magical about a recipe that checks every box – and this high-protein spinach artichoke chicken casserole does exactly that. Here’s why it’s become a weeknight hero in my kitchen:
• Uses everyday, affordable ingredients – No need for specialty items or expensive cuts of meat. Chicken breast, cottage cheese, and frozen spinach are budget-friendly staples that deliver maximum nutrition
• Prep in 20 minutes, then let the oven do the work – Perfect for those busy evenings when you want a home-cooked meal without the stress
• Incredibly versatile for any occasion – Elegant enough for dinner guests, comforting enough for a cozy family meal, and meal-prep friendly for the week ahead
• Sneaks vegetables into a crowd-pleasing format – Even the pickiest eaters will devour their greens when they’re nestled in this creamy, cheesy goodness
The real genius lies in the cottage cheese base. By blending it with garlic and seasonings, we create a protein-packed “cream” sauce that’s lighter than traditional versions but twice as satisfying.
Choosing the Right Chicken for High-Protein Spinach Artichoke Chicken Casserole
The foundation of any great chicken casserole starts with selecting and preparing your protein properly. Let me share what I’ve learned from years of working with chicken.
Best Cuts for This High-Protein Spinach Artichoke Chicken Casserole Recipe
Boneless, skinless chicken breasts are my go-to choice for this casserole, and here’s why: they’re lean, cook evenly when cubed, and provide the clean protein profile we’re after. The key is cutting them into uniform, bite-sized pieces – about 1-inch cubes work perfectly.
Chicken thighs can absolutely be substituted if you prefer a richer flavor and don’t mind the extra fat content. They’re more forgiving if you accidentally overcook them, but you’ll want to trim any excess fat before cubing.
Buying Tips for Your High-Protein Spinach Artichoke Chicken Casserole
When shopping for chicken breast, look for pieces that are similar in thickness – this ensures even cooking. The meat should be pale pink with no gray spots or strong odors. I always ask my butcher to pound the thicker pieces to an even thickness if I’m buying them whole.
Pro tip from my kitchen: If you’re buying in bulk, portion and freeze the chicken in casserole-sized amounts. There’s nothing more convenient than having pre-portioned protein ready for weeknight cooking!
Substitutions for High-Protein Spinach Artichoke Chicken Casserole
While chicken is classic, this casserole base works beautifully with other proteins:
- Turkey breast – Use the same preparation method
- Leftover rotisserie chicken – Shred it and add during the final mixing step
- Firm white fish like cod – Reduce cooking time slightly
- Plant-based option – Cubed extra-firm tofu or chickpeas for a vegetarian version
Ingredients & Prep for High-Protein Spinach Artichoke Chicken Casserole
Getting your prep work done right is what separates good cooks from great ones. Let me walk you through each component of this high-protein spinach artichoke chicken casserole.
Chicken Prep Essentials for High-Protein Spinach Artichoke Chicken Casserole
The secret to incredibly flavorful, moist chicken lies in a simple dry brine. Cut your 1 pound of boneless, skinless chicken breast into uniform bite-sized pieces, then generously season with kosher salt. Let this sit at room temperature for at least 20 minutes while you prep everything else.
This technique draws out moisture initially, then the salt dissolves and gets reabsorbed along with the natural juices – resulting in chicken that’s seasoned throughout and stays tender during cooking.
Cottage Cheese Magic in High-Protein Spinach Artichoke Chicken Casserole
Here’s where the protein power comes from: 16 ounces of cottage cheese (I prefer 4% for the creamiest texture) gets transformed into a luxurious sauce. The trick is blending it completely smooth with 2 peeled garlic cloves, ½ teaspoon kosher salt, ¼ teaspoon black pepper, and ¼ teaspoon onion powder.
Important note: Use a food processor or high-speed blender for this step. Hand mixing won’t achieve that silky texture that makes this casserole special.
Vegetable Prep for High-Protein Spinach Artichoke Chicken Casserole
The vegetables in this casserole need special attention:
Spinach preparation: Thaw 6 ounces of frozen chopped spinach completely, then squeeze out every drop of excess water using a clean dish towel. This step is non-negotiable – watery spinach will make your casserole soggy.
Artichoke preparation: Drain one 16-ounce can of artichoke hearts, then squeeze them in the same towel you used for the spinach. Don’t worry if they get a bit smashed – finely chop them after squeezing.
Step-by-Step Cooking Instructions for High-Protein Spinach Artichoke Chicken Casserole
Now for the fun part – bringing all these components together into casserole magic!
Pre-Cooking Prep for High-Protein Spinach Artichoke Chicken Casserole
Start by preheating your oven to 350°F. While it heats, make sure your brined chicken pieces are patted dry and your vegetables are properly squeezed and prepped. Have your blended cottage cheese mixture ready, and measure out ½ cup shredded mozzarella and ⅔ cup grated parmesan (you’ll reserve about ⅓ of these cheeses for topping).
Cooking Method for High-Protein Spinach Artichoke Chicken Casserole
Heat 1 teaspoon of avocado oil in a large pan over medium heat. Once hot, add your chicken pieces in a single layer – no overlapping! This is crucial for proper browning. Season with black pepper and cook for 2-3 minutes without moving them.
Flip the chicken and cook another 2-3 minutes until mostly done through. The chicken will finish cooking in the oven, so don’t worry about getting it completely cooked at this stage. Remove from pan and drain any excess liquid.
Assembly for High-Protein Spinach Artichoke Chicken Casserole
In your baking dish, combine the cooked chicken, squeezed spinach, chopped artichokes, blended cottage cheese mixture, and about ⅔ of your mozzarella and parmesan. Stir gently with a spatula until everything is evenly distributed, then smooth the top.
Final Cooking for High-Protein Spinach Artichoke Chicken Casserole
Cover tightly with foil and bake for 20 minutes. Remove the foil, sprinkle the remaining cheese on top, and return to the oven uncovered for 10 more minutes. For that perfect golden, bubbly top, switch to broil for the last 2-3 minutes.
Temperature check: The internal temperature should reach 165°F for food safety, and the center should be hot and bubbly throughout.
Resting Your High-Protein Spinach Artichoke Chicken Casserole
Let the casserole rest for 5-10 minutes before serving. This allows the flavors to settle and makes it easier to serve without everything falling apart. Trust me on this – the wait is worth it!
Pro Tips for Perfect High-Protein Spinach Artichoke Chicken Casserole
After making this casserole countless times, here are the secrets I’ve learned for guaranteed success.
Avoiding Common Mistakes with High-Protein Spinach Artichoke Chicken Casserole
The biggest mistake? Not properly draining the vegetables. Excess water is the enemy of a good casserole – it creates a watery, separated mess instead of the creamy consistency we want.
Don’t overcrowd the pan when cooking chicken. Cook in batches if necessary. Overcrowded chicken steams instead of browning, and you’ll miss out on that crucial flavor development.
Blend that cottage cheese completely – any lumps will be noticeable in the final dish. If you don’t have a food processor, use an immersion blender or even push the mixture through a fine mesh strainer.
Essential Tools for High-Protein Spinach Artichoke Chicken Casserole
- Food processor or high-speed blender – For silky smooth cottage cheese mixture
- Large skillet – For properly browning the chicken
- 9×13 inch baking dish – The perfect size for this recipe
- Clean dish towels – Essential for squeezing vegetables dry
- Instant-read thermometer – Takes the guesswork out of doneness
Storage & Reheating High-Protein Spinach Artichoke Chicken Casserole
This casserole keeps beautifully! Store covered in the refrigerator for up to 4 days. To reheat, cover with foil and warm in a 325°F oven until heated through, about 20-25 minutes.
For longer storage, this casserole freezes wonderfully for up to 3 months. Thaw completely in the refrigerator before reheating. You might need to add a splash of chicken broth if it seems dry after thawing.
Flavor Variations for High-Protein Spinach Artichoke Chicken Casserole
One of my favorite things about this high-protein spinach artichoke chicken casserole is how adaptable it is to different flavor profiles and dietary needs.
Spicy High-Protein Spinach Artichoke Chicken Casserole
Add ½ teaspoon cayenne pepper to the cottage cheese mixture, or stir in 2-3 minced chipotle peppers in adobo sauce. The smoky heat pairs beautifully with the creamy base. For extra kick, top with pepper jack cheese instead of mozzarella.
Keto-Friendly High-Protein Spinach Artichoke Chicken Casserole
This recipe is naturally keto-friendly, but you can boost the fat content by using full-fat cottage cheese and adding an extra ½ cup of cheese. Serve over cauliflower rice or zucchini noodles instead of traditional sides.
Global Flavors for High-Protein Spinach Artichoke Chicken Casserole
Mediterranean twist: Add sun-dried tomatoes, kalamata olives, and fresh basil. Replace parmesan with crumbled feta cheese.
Italian herb version: Mix in dried oregano, basil, and Italian seasoning. Top with fresh mozzarella and a sprinkle of red pepper flakes.
Mexican-inspired: Add cumin, chili powder, and diced green chiles. Top with Mexican cheese blend and serve with avocado and cilantro.
| Variation | Key Additions | Cheese Swap | Serving Suggestion |
|---|---|---|---|
| Mediterranean | Sun-dried tomatoes, olives, basil | Feta cheese | With Greek salad |
| Italian Herb | Oregano, basil, Italian seasoning | Fresh mozzarella | With garlic bread |
| Mexican-Inspired | Cumin, chili powder, green chiles | Mexican blend | With avocado, cilantro |
| Spicy | Chipotle peppers, cayenne | Pepper jack | With cooling cucumber salad |
Serving Suggestions for High-Protein Spinach Artichoke Chicken Casserole
This versatile casserole pairs beautifully with a variety of sides, making it perfect for any occasion.
Light and fresh sides balance the richness perfectly: a simple arugula salad with lemon vinaigrette, roasted asparagus with garlic, or steamed broccoli with a squeeze of lemon.
Heartier accompaniments turn this into a feast: creamy mashed cauliflower (or traditional potatoes), roasted root vegetables, or crusty artisan bread for sopping up every delicious bit.
Wine pairings: A crisp Sauvignon Blanc or Pinot Grigio complements the creamy richness, while a light Chardonnay enhances the cheese flavors. For red wine lovers, try a light Pinot Noir.
Beer pairings: A wheat beer or pilsner cuts through the richness nicely, while a light IPA adds a hoppy contrast to the creamy elements.
FAQs About High-Protein Spinach Artichoke Chicken Casserole
Can I use frozen chicken in this high-protein spinach artichoke chicken casserole?
Yes, but thaw it completely first and pat it very dry. Frozen chicken releases more moisture during cooking, which can affect the casserole’s texture. The dry brining step becomes even more important with previously frozen chicken.
How do I fix an overcooked high-protein spinach artichoke chicken casserole?
If your chicken becomes tough, try adding a splash of chicken broth and covering with foil for the remainder of cooking time. The steam will help rehydrate the meat. Prevention is key – use a thermometer and don’t exceed 165°F internal temperature.
Is this high-protein spinach artichoke chicken casserole safe during pregnancy?
Yes, as long as the chicken reaches an internal temperature of 165°F and all dairy products are pasteurized (which store-bought cottage cheese and cheese typically are). Always consult with your healthcare provider about specific dietary concerns during pregnancy.
Can I make this high-protein spinach artichoke chicken casserole ahead of time?
Absolutely! Assemble the casserole up to 24 hours in advance and store covered in the refrigerator. Add about 10 extra minutes to the covered cooking time since you’re starting with a cold dish.
What’s the protein content of this high-protein spinach artichoke chicken casserole?
Each serving provides approximately 35-40 grams of protein, thanks to the combination of chicken breast and cottage cheese. This makes it an excellent choice for those following high-protein diets or looking to increase their protein intake.
Conclusion
There you have it – your complete guide to creating the most satisfying, protein-packed comfort food that doesn’t compromise on flavor or nutrition! This high-protein spinach artichoke chicken casserole has become one of my most requested recipes, and I know it’s going to become a staple in your kitchen too.
Ready to make magic happen in your kitchen? Gather these simple ingredients tonight and treat yourself to a meal that nourishes both body and soul. There’s something so rewarding about pulling a golden, bubbly casserole from the oven and knowing you’ve created something that’s both delicious and nutritious.
Join the thousands of home cooks who’ve fallen in love with this recipe – and don’t forget to share your creations! I love seeing how you make this dish your own.
Craving more comfort food with a healthy twist? Check out my [Protein-Packed Stuffed Bell Peppers] and [Creamy Chicken and Vegetable Skillet] for more weeknight dinner inspiration that proves healthy eating never has to be boring!
If you enjoyed this recipe, be sure to share it with your friends or save it for later!
I’d love to see your unique twist—feel free to post your photos on Pinterest!
Happy cooking! – Emeli
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High-Protein Spinach Artichoke Chicken Casserole: 5 Secrets Perfect
- Total Time: 50mins
Description
This High-Protein Spinach and Artichoke Chicken Casserole elevates your favorite dip into a meal that’s as nourishing as it is delicious. With 47 grams of protein per serving, this dish is ideal for keeping you full and fueled. The secret is to add chicken breast and blended cottage cheese to boost the protein while keeping that same, indulgent spinach artichoke flavor and experience.
Ingredients
16 oz cottage cheese (4% preferred)
2 garlic cloves peeled
½ tsp kosher salt
¼ tsp black pepper
¼ tsp onion powder
1 tsp avocado oil or olive oil
1 lb boneless, skinless chicken breast cut into bite-sized pieces
kosher salt to taste
black pepper to taste
½ cup low-moisture, part skim, finely shredded mozzarella cheese
⅔ cup finely grated parmesan cheese
1 can artichoke hearts (16oz), drained
6 oz frozen chopped spinach thawed
Instructions
Preheat oven to 350F.
Optional but encouraged: If time allows, heavily season the cubed chicken breast with kosher salt and let it sit at room temperature for 20+ minutes, or while you prepare the remaining ingredients. This acts as a “dry brine” to yield moist & flavorful chicken!
1 lb boneless, skinless chicken breast,kosher salt
Place your artichoke hearts into a thin dish towel, cheesecloth or paper towel and squeeze out all the excess liquid. It’s okay if the artichokes get a bit smushed in the process! Then, finely chop them up and set aside.
1 can artichoke hearts
Use the same dish towel to then squeeze out all the excess liquid from the thawed spinach. Don’t skip this step!
6 oz frozen chopped spinach
Bring a large pan to medium heat. Once hot, add the oil. Then, add the cubed chicken and spread it out in the pan so that there’s no overlap. Season with black pepper. Cook for 2-3 minutes, then flip and continue cooking for 2-3 more minutes, until mostly done through. Remove chicken from the pan, draining off any excess grease/liquid, and set aside.
1 tsp avocado oil,black pepper
In a small food processor, add the cottage cheese, garlic, salt, pepper and onion powder. Blend until smooth.
16 oz cottage cheese,2 garlic cloves,½ tsp kosher salt,¼ tsp black pepper,¼ tsp onion powder
To your baking dish add the cooked chicken, spinach, artichokes, blended cottage cheese and about ⅔ of the mozzarella and parmesan (reserving the rest for topping). Stir with a spatula until combined and then spread out evenly in the baking dish.
½ cup low-moisture, part skim, finely shredded mozzarella cheese,⅔ cup finely grated parmesan cheese
Cover the baking dish with foil and transfer to the oven for 20 minutes.
Remove the foil, sprinkle the remaining mozzarella and parmesan evenly over top, and transfer back to the oven to bake, uncovered, for 10 more minutes. I like to switch to broil for a few minutes at the end to get a golden, bubbly crust. Enjoy!
- Prep Time: 10 minutes
- Cook Time: 40 minutes
- Category: Dinner
- Cuisine: American
Nutrition
- Serving Size: 4 people
- Calories: 404kcal
- Sugar: 4g
- Sodium: 1620mg
- Fat: 1g
- Saturated Fat: 7g
- Trans Fat: 0.01g
- Carbohydrates: 13g
- Fiber: 3g
- Protein: 47g
- Cholesterol: 116mg
Keywords: High-Protein Spinach Artichoke Chicken Casserole