High-Protein Spinach Artichoke Chicken Casserole – Creamy & Nutritious Comfort Food

High-Protein Spinach Artichoke Chicken Casserole just saying it makes my mouth water. You know that feeling when you’re craving something creamy and comforting, but you also want to feel good about what you’re eating? That’s exactly why I created this recipe.

I’m Emeli, and I’ve spent years chasing flavor around the world from bustling street markets to quiet home kitchens where grandmothers guard their secrets. But here’s what I’ve learned: the most satisfying meals are the ones that love you back. This casserole does exactly that. It’s packed with lean protein, creamy Greek yogurt instead of heavy cream, and all those spinach-artichoke flavors we crave from our favorite dip but transformed into a complete, nourishing meal.

Tired of dry, overcooked chicken breasts that taste like cardboard? This High-Protein Spinach Artichoke Chicken Casserole promises tender, juicy chicken smothered in a luxurious sauce that’s secretly good for you. After years of experimenting in both professional kitchens and my own home, I’ve mastered the art of creating comfort food that actually fuels your body.

In this guide, I’ll walk you through choosing the right chicken, prepping your ingredients for maximum flavor, and cooking techniques that guarantee perfect results every time. Plus, I’ll share my favorite variations and answer all your burning questions about making this recipe work for your lifestyle.

Why This High-Protein Spinach Artichoke Chicken Casserole Works

This recipe is my answer to busy weeknights when you need something impressive but don’t have hours to spend in the kitchen. Here’s why it’s become a staple at FoodFansy:

• Protein-Packed Nutrition: With lean chicken breast and protein-rich Greek yogurt, you’re getting over 40g of protein per serving perfect for fitness goals or just feeling satisfied longer
• One-Dish Wonder: Everything bakes together in a single casserole dish, meaning minimal cleanup and maximum flavor development
• Prep-Ahead Friendly: Assemble the entire casserole in the morning, refrigerate it, and pop it in the oven when you get home dinner in 30 minutes
• Budget-Conscious Comfort: Uses affordable chicken breasts and pantry staples, with frozen spinach working just as beautifully as fresh
• Crowd-Pleasing Versatility: Equally at home at a family dinner, meal prep Sunday, or potluck gathering

Choosing the Right Chicken for High-Protein Spinach Artichoke Chicken Casserole

The foundation of any great chicken dish starts with selecting quality meat. Let me share what I’ve learned from years of working with poultry.

Best Cuts for This High-Protein Spinach Artichoke Chicken Casserole

Boneless, skinless chicken breasts are my go-to for this recipe because they provide lean protein without excess fat, allowing the creamy sauce to shine. Look for breasts that are roughly the same size (about 6-8 oz each) so they cook evenly. If your breasts are particularly thick, butterfly them or pound them to an even thickness this prevents the dreaded dry edges while the center finally cooks through.

Chicken tenderloins work beautifully too and cook even faster. They’re naturally tender and perfect for portion control.

Chicken thighs can be substituted if you prefer dark meat’s richer flavor and more forgiving texture. They’ll add about 5 minutes to the cooking time and increase the fat content slightly, but the trade-off is nearly impossible-to-overcook juiciness.

Buying Tips for High-Protein Spinach Artichoke Chicken Casserole

When I’m at the butcher counter or grocery store, I look for chicken with a fresh, slightly sweet smell never sour or ammonia-like. The meat should be pink with a subtle sheen, not gray or slimy. Check the sell-by date and choose packages with the furthest date out.

If possible, opt for organic or free-range chicken. The difference in texture and flavor is noticeable, and you’re supporting better farming practices. That said, this recipe is forgiving enough that conventional chicken works perfectly well too.

Substitutions for High-Protein Spinach Artichoke Chicken Casserole

Turkey cutlets provide similar lean protein with a slightly earthier flavor. For a pescatarian twist, thick cod or halibut fillets work surprisingly well just reduce the cooking time to 15-20 minutes.

Ingredients & Prep for High-Protein Spinach Artichoke Chicken Casserole

Let me walk you through everything you need to create this comforting masterpiece.

Meat Prep Essentials for High-Protein Spinach Artichoke Chicken Casserole

Start by trimming any excess fat or silverskin from your chicken breasts this ensures even cooking and better texture. Pat them completely dry with paper towels; moisture is the enemy of good browning and seasoning adhesion.

Season both sides generously with salt, pepper, and garlic powder. Here’s my secret weapon: toss the seasoned chicken with 2-3 tablespoons of Greek yogurt and let it rest for 15 minutes at room temperature. The yogurt’s lactic acid gently tenderizes the meat while keeping it incredibly moist during baking. This step transformed my chicken game, and I never skip it.

Creamy Sauce Base for High-Protein Spinach Artichoke Chicken Casserole

The magic of this recipe lies in its protein-rich, lighter-than-traditional sauce:

• 1 ½ cups Greek yogurt (use full-fat for richest flavor, 2% for a lighter option)
• 1 cup part-skim mozzarella cheese, shredded (the melting cheese that creates that irresistible pull)
• ½ cup Parmesan cheese, freshly grated (please, no pre-grated it doesn’t melt the same)
• 1 cup chopped spinach, fresh or frozen (if frozen, squeeze out every drop of water seriously, wring it like you’re angry)
• 1 cup chopped artichoke hearts, canned or jarred (I prefer marinated for extra flavor, but rinse them if using brined)
• 2 cloves garlic, minced (or 3 if you’re a garlic lover like me)
• Salt and pepper to taste (start with ½ teaspoon each)

Pantry Staples for High-Protein Spinach Artichoke Chicken Casserole

You’ll need olive oil for coating your casserole dish about 1 tablespoon does the trick. To elevate the flavor profile, raid your spice cabinet for paprika (adds beautiful color and subtle smokiness), onion powder (deepens the savory notes), or Italian herb blend (brings restaurant-quality complexity). A pinch of red pepper flakes adds warmth without overwhelming heat.

Step-by-Step Cooking Instructions for High-Protein Spinach Artichoke Chicken Casserole

Let me guide you through each stage to ensure perfect results every single time.

Pre-Cooking Prep – High-Protein Spinach Artichoke Chicken Casserole

Preheat your oven to 375°F (190°C) this moderate temperature ensures the chicken cooks through without drying out while giving the cheese time to become gloriously golden and bubbly.

Lightly coat a 9×13-inch casserole dish with olive oil or cooking spray. Arrange your seasoned chicken pieces in a single layer with a bit of space between them. Overcrowding creates steam instead of that slightly caramelized exterior we’re after.

Cooking Method – High-Protein Spinach Artichoke Chicken Casserole

In a large mixing bowl, combine the Greek yogurt, mozzarella, Parmesan, spinach, artichokes, minced garlic, and your chosen spices. Mix thoroughly until everything is evenly distributed you want every bite to have those perfect pockets of spinach and artichoke.

Spoon the creamy mixture generously over each piece of chicken, spreading it to the edges and letting some cascade between the pieces. Don’t be shy here; that sauce is where the magic happens.

Slide the casserole into your preheated oven and bake uncovered for 25-30 minutes. You’ll know it’s ready when the sauce is bubbling enthusiastically around the edges and the top has developed those golden-brown spots that promise maximum flavor.

Doneness Check – High-Protein Spinach Artichoke Chicken Casserole

This is non-negotiable: invest in an instant-read meat thermometer if you don’t have one already. Insert it into the thickest part of the largest chicken breast you’re looking for exactly 165°F (74°C). At this temperature, the chicken is perfectly cooked: safe to eat, juicy, and tender.

If you’re not quite there yet, return the casserole to the oven and check again in 5-minute intervals. Remember, the chicken will continue cooking slightly during the resting period.

Resting – High-Protein Spinach Artichoke Chicken Casserole

Patience, my friend. Let the casserole rest for 5 minutes before serving. During this time, the sauce thickens beautifully as it cools slightly, and the chicken reabsorbs its juices, ensuring every bite is as moist as possible. Use this time to prepare your sides or set the table you’ve earned it.

Pro Tips for Perfect High-Protein Spinach Artichoke Chicken Casserole

After making this recipe countless times (and teaching it to my FoodFansy community), here are the tricks that separate good from extraordinary.

Avoiding Tough or Dry Chicken in High-Protein Spinach Artichoke Chicken Casserole

Don’t skip the yogurt marinade – those 15 minutes make an incredible difference. The enzymes in yogurt break down tough proteins, creating fork-tender results.

Pound to even thickness – if you have a meat mallet, pound thicker breasts to about ¾-inch uniform thickness. This ensures everything finishes cooking at the same time.

Cover with foil if browning too quickly – if your cheese is getting dark before the chicken reaches temperature, tent the casserole loosely with aluminum foil for the remaining cooking time.

Let it come to room temp – take the chicken out of the fridge 20 minutes before cooking. Cold meat straight from the fridge cooks unevenly, with the outside overcooking before the inside is done.

Tool Recommendations for High-Protein Spinach Artichoke Chicken Casserole

Instant-read meat thermometer – I cannot stress this enough. It’s the difference between guesswork and perfection ($15-30 well spent).

Quality casserole dish – ceramic or glass retains heat beautifully and creates those crispy edges everyone fights over. I love my 9×13-inch stoneware dish.

Microplane grater – for freshly grated Parmesan that melts like a dream, unlike the sawdust-textured pre-grated stuff.

Storage & Reheating High-Protein Spinach Artichoke Chicken Casserole

Store leftovers in an airtight container in the refrigerator for up to 4 days. The flavors actually deepen overnight, making it excellent meal prep.

To reheat, add a splash of chicken broth or milk to restore moisture, cover with foil, and warm in a 350°F oven for 15-20 minutes. Microwave individual portions for 2-3 minutes, stopping to stir halfway through.

For freezing, cool completely, portion into freezer-safe containers, and freeze for up to 3 months. Thaw overnight in the fridge before reheating. The texture holds up remarkably well.

Flavor Variations for High-Protein Spinach Artichoke Chicken Casserole

This base recipe is incredibly versatile. Here are my favorite ways to switch things up depending on mood or dietary needs.

Spicy Twist on High-Protein Spinach Artichoke Chicken Casserole

Transform this into a kicked-up version by adding ½ teaspoon cayenne pepper to the sauce or diced jalapeños mixed with the spinach and artichokes. Pepper jack cheese substituted for half the mozzarella brings creamy heat. Top with crushed red pepper flakes before baking for those who like to live dangerously.

Keto/Paleo High-Protein Spinach Artichoke Chicken Casserole

This recipe is naturally low-carb and keto-friendly as written! To make it dairy-free for Paleo diets, swap the Greek yogurt for coconut cream (the thick part from a chilled can of full-fat coconut milk) and use nutritional yeast instead of Parmesan for that savory, cheesy flavor. Omit the mozzarella or use a dairy-free alternative.

Global Flavors for High-Protein Spinach Artichoke Chicken Casserole

Mediterranean: Add sun-dried tomatoes, kalamata olives, and fresh oregano. Substitute feta for some of the mozzarella.

Italian: Mix in pesto (2-3 tablespoons) with the yogurt base and top with fresh basil after baking. A sprinkle of pine nuts adds elegant crunch.

Mexican: Use pepper jack cheese, add cumin and chili powder, fold in black beans and corn, and top with fresh cilantro and lime juice after baking.

Asian-Inspired: Replace spinach with bok choy, add ginger and sesame oil to the sauce, and finish with sesame seeds and sliced green onions.

Flavor Variations Comparison Table

Serving Suggestions for High-Protein Spinach Artichoke Chicken Casserole

This casserole is substantial enough to stand alone, but pairing it with complementary sides creates a complete, memorable meal.

Vegetable Sides: Roasted asparagus with lemon zest, garlic green beans, or a crisp arugula salad with balsamic vinaigrette cuts through the richness beautifully. Roasted broccoli or cauliflower adds substance without competing flavors.

Starches: Serve over fluffy quinoa, wild rice, or cauliflower rice for a low-carb option. Creamy mashed potatoes or garlic herb roasted potatoes make this feel like Sunday dinner. A warm, crusty baguette for soaking up that incredible sauce is non-negotiable in my house.

Wine Pairings: The creamy, garlicky profile pairs beautifully with a crisp Sauvignon Blanc or Pinot Grigio – the acidity cuts through the richness. For red wine lovers, try a light-bodied Pinot Noir that won’t overwhelm the delicate chicken.

Beer Pairings: A wheat beer or Hefeweizen with its subtle sweetness complements the artichokes, while a crisp pilsner refreshes the palate between bites.

FAQs About High-Protein Spinach Artichoke Chicken Casserole

Let me answer the questions I hear most often from the FoodFansy community.

Can I use frozen chicken for High-Protein Spinach Artichoke Chicken Casserole? Technically yes, but I strongly recommend thawing it first. Frozen chicken releases excess moisture during cooking, which can make your sauce watery and prevent proper browning. If you’re in a pinch, thaw it safely in the refrigerator overnight or use the cold water method (sealed in a bag, submerged in cold water for 1-2 hours).

How do I fix overcooked chicken in this casserole? If you’ve already overcooked it, shred the chicken and mix it thoroughly with the sauce – this redistributes moisture and makes the dryness less noticeable. For next time, check temperature early (around 20 minutes) and remember that carryover cooking will add another 5°F after removing from the oven.

Can I make High-Protein Spinach Artichoke Chicken Casserole ahead of time? Absolutely! Assemble the entire casserole up to 24 hours in advance, cover tightly with plastic wrap, and refrigerate. When ready to cook, let it sit at room temperature for 20 minutes, then bake as directed, adding 5-10 extra minutes to account for the cold start.

Is High-Protein Spinach Artichoke Chicken Casserole safe during pregnancy? Yes! As long as the chicken reaches the safe internal temperature of 165°F, this recipe is pregnancy-safe. The Greek yogurt provides beneficial probiotics, and the spinach offers folate and iron nutrients especially important during pregnancy. Just ensure all cheeses used are pasteurized.

Can I double this recipe for a crowd? Definitely! Use two 9×13-inch dishes rather than one giant pan this ensures even cooking. Alternatively, you can use a large roasting pan, but you may need to add 10-15 minutes to the cooking time. Always verify internal temperature rather than relying on time alone.

What if I don’t have Greek yogurt? Regular sour cream works as a 1:1 substitute, though it’s slightly higher in fat and lower in protein. In a pinch, use softened cream cheese thinned with a bit of milk, though you’ll sacrifice some of the protein benefits.

Why is my sauce watery? The most common culprit is not squeezing the spinach dry enough (if using frozen) or not draining the artichoke hearts. Also, if you skip bringing the chicken to room temperature, excess condensation can create a watery sauce. Fix it by spooning off excess liquid or thickening with a tablespoon of cornstarch mixed with cold water before baking.

Conclusion

There you have it my High-Protein Spinach Artichoke Chicken Casserole, a recipe born from my belief that comfort food should comfort your body as much as your soul. This is the kind of meal that makes weeknight dinners feel special without demanding hours of your time or requiring specialty ingredients.

The beauty of this casserole is its forgiving nature and endless adaptability. Whether you’re cooking for your family, meal prepping for the week, or bringing a dish to share, this recipe delivers consistent, crowd-pleasing results. The combination of tender chicken, creamy sauce, and those beloved spinach-artichoke flavors creates something truly satisfying.

Fire up your oven and try this tonight! Start with the classic version, then let your creativity run wild with the variations. There’s something deeply satisfying about pulling a bubbling, golden casserole from the oven it’s the kind of moment that makes all the kitchen time worthwhile.

Join the thousands of home cooks in the FoodFansy community who’ve made this recipe a regular in their rotation! Share your variations, tips, and photos I love seeing how you make this recipe your own.

If you enjoyed this recipe, be sure to share it with your friends or save it for later! I’d love to see your unique twist feel free to post your photos on Pinterest!

High-Protein Spinach Artichoke Chicken Casserole – Creamy & Nutritious Comfort Food

---

• Author: Emily
• Total Time: 40 minutes
• Yield: 4 servings 1x

Print Recipe

Pin Recipe

Description

This High-Protein Spinach Artichoke Chicken Casserole is creamy, cheesy, and packed with protein for a satisfying and nutritious dinner.

---

Ingredients

Scale 1x2x3x

2 lbs boneless, skinless chicken breasts

1 ½ cups Greek yogurt

1 cup mozzarella cheese

½ cup Parmesan cheese

1 cup chopped spinach

1 cup chopped artichoke hearts

2 cloves garlic, minced

1 tbsp olive oil

Salt and pepper to taste

---

Instructions

1. Preheat oven to 375°F (190°C).

2. Grease a casserole dish and layer chicken evenly.

3. Mix yogurt, cheeses, spinach, artichokes, garlic, and spices.

4. Spread mixture over chicken.

5. Bake for 25–30 minutes until bubbly and golden.

6. Let rest 5 minutes before serving.

Notes

Store leftovers in the fridge up to 3 days.

Reheat in the oven or microwave before serving.

• Prep Time: 10 minutes
• Cook Time: 30 minutes
• Category: Dinner
• Method: Baking
• Cuisine: American

Nutrition

• Serving Size: 1 portion
• Calories: 280
• Sugar: 3g
• Sodium: 420mg
• Fat: 12g
• Saturated Fat: 5g
• Unsaturated Fat: 6g
• Trans Fat: 0g
• Carbohydrates: 6g
• Fiber: 1g
• Protein: 35g
• Cholesterol: 70mg

Keywords: High-Protein Spinach Artichoke Chicken Casserole, healthy dinner, easy casserole